Human/animal chimeras may also help fill in the gaps in our understanding of the following early human development conceptFarahany and Greely said and improved research on how viruses, bacteria, drugs and devices work in humans.
“The animal models we currently have are not enough to simulate most of the diseases that humans suffer-especially Brain disease Farahani said: “The disease that humans suffer is actually any disease. This means that when you try to test a drug or try to understand the occurrence or development of a certain disease, we don’t have a good model to do it now.”
For example, this human/animal chimera can help us better understand why Zika virus Farahani said this will cause birth defects in the children of the infected pregnant women.
In 2017, members of the research team reported that they had incorporated human cells into early pig tissues, but the contribution of human cells was quite low.
Therefore, the researchers set out to create a chimera in the macaque macaque, a species more closely related to humans.
Six days after creating 132 monkey embryos in the laboratory, each embryo was injected with 25 human stem cells.
After 10 days, 103 chimeric embryos are still developing. Survival soon began to decline, and by day 19, only three chimeras were still alive.
The researchers say that it is important that human cells maintain a high percentage of the embryos throughout the process-which means that human cells are integrating into the host monkey species.
Professor Juan Carlos Espisua Belmonte, a professor at the Gene Expression Laboratory of the Salk Institute for Biology in La Jolla, California, said: “Human cells survive inside monkey embryos, proliferate and produce several …Cell lineage.”
Izpisua Belmonte said in a press release that the production of this human/monkey chimera “will allow us to better understand whether there are evolutionary barriers to chimera production, and whether There is any way to overcome them.”
Greeley said: “People have always hoped that human cells can work better in monkey embryos. They can figure out why they work better in monkey embryos and use this knowledge to make them work better in pig embryos. Work hard.”