Obesity increases the chance of breast cancer recurrence

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Cara Murez
Health Day reporter

Monday, April 19, 2021 (HealthDay News)-most people know obesity Can lead to diabetes or heart disease, But redundant weight allowable cancerThe researchers said so.

A new study found Breast cancer The survivors are overweight The risk of developing a second primary cancer is statistically significantly increased, and the second primary cancer is not related to the previous cancer.

This risk may be due to common risk factors between the two cancers (obesity is one of them), as well as genetic susceptibility and long-term effects. Breast Cancer Treatment, The study author said.

“This risk is comparable to our initial risk of breast cancer,” said Heather Spencer Feigelson, a senior researcher at the Kaiser Institute for Permanent Health in Colorado in Aurora. “This is just another piece of evidence that shows us [excess weight] It’s really important. “

In this study, the researchers reviewed data on nearly 6,500 women treated at Kaiser Permanente in Colorado and Washington. The percentages of normal weight, overweight and obesity are roughly equal.

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Woman has one Invasive breast cancer The risk of developing the second type of cancer is small, but significantly higher body mass index Research findings (BMI) have increased. (BMI is body fat estimated based on height and weight.)

The researchers say that this connection is even more pronounced when the analysis focuses on obesity-related cancers or the second type of breast cancer. This link is the strongest for the diagnosis of estrogen receptor-positive second breast cancer.

Feigelson said that of the 14 types of obesity-related cancers listed by the International Agency for Research on Cancer, some are common and some are more difficult to treat.

Researchers found that after an average follow-up of more than 7 years, 822 women (nearly 13%) had a second type of cancer. Among them, nearly 62% are cancers related to obesity, and 40% are second breast cancers.

508 cases of obesity-related cancers include 283 cases of postmenopausal breast cancer. 70 cases of colon/rectal cancer; 68 cases of uterine cancer; 21 types of ovarian cancer; 23 types of pancreatic cancer; and 14 types of kidney cancer. Thyroid, esophagus, thyroid, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, thyroid cancer, gastric cancer, gastric cancer, gastric cancer, gastric cancer, etc., less than 10 cases per case gallbladder, Multiple myeloma, meningioma, liver cancer and upper gastric cancer.

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Fegelson said that although being overweight seems to increase the risk, there is limited evidence to lose weight and maintain weight to lose weight because it is difficult to lose weight.

“Science shows that, yes, if you lose weight, you should reduce your risk, but in fact the best research… is for women with obesity. [weight-loss] Surgery, those who lose weight do have a lower risk of cancer,” Ferguson said.

Approximately 55% of all cancers in women occur in women who are overweight or obese.

Feigelson pointed out that women have many risk factors for breast cancer that cannot be resolved.

She said: “For example, for these second breast cancers or second cancers after breast cancer, one risk factor is treatment. Obviously you will not give up treatment.” “But this is what women can actually control. Things. I think if you are worried about cancer or you are a cancer survivor, it is very important for you to have things that you can control and make a difference.”

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Develop some healthy habits in daily life can help prevent cancer. Feigelson recommends maintaining a healthy weight, staying active, and not sitting too much.

The findings were recently published in Journal of the National Cancer Institute.

The researchers pointed out that the limitation of this study is the lack of diversity, because about 82% of the participants were white women.

Dr. Jennifer Ligibel, director of the Zakim Comprehensive Therapy and Healthy Living Center at the Dana-Farber Cancer Institute in Boston, reviewed the results of the study.

She said: “I think this paper does provide a compelling reason why it is important to consider weight loss after being diagnosed with breast cancer.”

Ligibel said that being overweight has many effects on the human body, increasing the level of insulin and other metabolic indicators and inflammation. She added that this might also lower the immune system.

In addition, she pointed out that being overweight will increase the level of sex hormones, which may also lead to the development of certain types of cancer.

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Ligibel said: “This may not be the same thing, but the complex interaction between these different systems.” He is part of another study, which is a weight loss program as part of breast cancer treatment. , Whether it can reduce the incidence of new cancers.

She pointed out that over the years, the American Cancer Society has made recommendations on nutrition, physical activity and weight for cancer and cancer survivors. This includes trying to reach and maintain a healthy weight.

“Unfortunately, [a lot of people have] Last year’s quarantine and all other measures increased weight, but I think this is a goal that we really need to consider at the social level,” Ligibel said.

More information

The U.S. Centers for Disease Control and Prevention introduced in detail Adult obesity.

Source: Dr. Heather Spencer Feigelson, a cancer epidemiologist and senior researcher at the Kaiser Institute for Permanent Health in Aurora, Colorado. Jennifer Ligibel, MD, associate professor at Harvard Medical School School of Medicine, director of the Leonard P. Zakim Center for Comprehensive Therapy and Healthy Life at Dana-Farber Cancer Institute in Boston; Journal of the National Cancer Institute, April 5, 2021

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