Many children who develop severe MIS-C have neurological symptoms


Robert Preidt and Ernie Mundell

Health Day reporter

Wednesday, April 14, 2021 (HealthDay News)-In rare cases, children are infected Novel Coronavirus A serious disease called Multiple System Inflammatory Syndrome (MIS-C) develops. Now, studies have found that these young patients often have neurological symptoms and may face respiratory diseases.

British researchers say these neurological symptoms appear in half of the children hospitalized for MIS-C.

Study author Dr. Omar Abdul Mannan of University College London said: “As children are infected with this new inflammatory syndrome, we are still studying how this syndrome affects children and what we need What to pay attention to.” His team plans to present the new findings at the virtual annual meeting of the American Academy of Neurosciences this month.

“We found that many children have experienced neurological symptoms involving the central nervous system and peripheral nervous system,” the researchers explained in the college press release.

MIS-C is a rare disease that usually occurs in children who have previously been infected with COVID-19. It usually starts about a month after someone is infected with COVID-19.

The disease is marked by a large influx inflammation Affect the function of organs and systems throughout the body. Although the exact cause is still unclear, MIS-C seems to be rooted in the human immune system and overreacts to the COVID-19 virus. Many children with MIS-C require hospitalization, but the treatment is usually successful and most children can recover. However, scientists and doctors are still studying the potential long-term effects.

In this new study, Abdel-Mannan’s team analyzed 46 MIS-C patients under 18 years of age (average age 10) who were admitted to London’s Great Ormond Street Hospital between April and September last year with COVID-19. Medical history.

Of these children, 24 showed new neurological symptoms or signs on admission. 24 headaches, 14 headaches Encephalopathy (Sometimes due to inflammation of the brain caused by infection), 6 had abnormal voice or hoarseness, 6 had hallucinations, 5 had impaired coordination (ataxia), 3 had peripheral nerve problems and 1 had seizures .

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Researchers say that children with neurological symptoms are more likely to develop MIS-C than children without such symptoms, so that they need ventilators and drugs to help stabilize their blood circulation.

Abdel-Mannan believes: “The neurological symptoms and longer-term cognitive outcomes of children in this situation should definitely be evaluated.” He added: “More research is needed to allow more children and more children. Let’s study how this situation changes over time and whether it has long-term neurocognitive effects.”

An expert in the United States said that the new discovery provides valuable insights into what is still a mysterious disease.

“This research provides an important basis for solving the MIS-C problem,” said Dr. Michael Grosso, Chief Medical Officer and Director of Pediatrics at Northwell Health Huntington Hospital in Huntington, New York.

He said: “Multisystem inflammatory syndrome seems to overlap with a well-known childhood Kawasaki disease, but it is also different in many ways, and its manifestation also depends on the child’s age.” “The author found that the central nervous system is affected It is very common in MIS-C, which may be of great help in reminding clinicians to look for these problems.”

But Grosso added that the research is still in its infancy.

He said: “So far, our understanding of COVID and MIS-C in children is very likely, but this is only a small part of what needs to be learned.”

Since new discoveries are presented at medical conferences, they should be considered preliminary findings before being published in peer-reviewed journals.

More information

The U.S. Centers for Disease Control and Prevention Multiple system inflammatory syndrome in children.

Source: Michael Grosso, MD, Chief Medical Officer and Chair of Pediatrics, Huntington Hospital, Northwell Health District, Huntington, NY; American Academy of Neurology, press release, April 13, 2021

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